About cookies on this site Our websites require some cookies to function properly (required). In addition, other cookies may be used with your consent to analyze site usage, improve the user experience and for advertising. For more information, please review your options. By visiting our website, you agree to our processing of information as described in IBM’sprivacy statement. To provide a smooth navigation, your cookie preferences will be shared across the IBM web domains listed here.
Conference paper
Microfluidic selection of library elements
Abstract
We demonstrate that biological libraries can be screened using microfluidics. A bacteriophage library encoding dodecapeptides is passed through a microfluidic chip wherein antibodies are immobilized. Bacteriophages exhibiting affinity for the antibody are retained and eluted in a subsequent step. The high degree of control over flow and binding conditions during the screening enables dramatic reduction of the native library in favor of bacteriophages binding to the antibody target. © 2008 CBMS.