William Hinsberg, Joy Cheng, et al.
SPIE Advanced Lithography 2010
An optimal electrode position, atrio-ventricular (AV) and interventricular (VV) delay in cardiac resynchronization therapy (CRT) improves its success. An optimization strategy does not yet exist. A computer model of the Visible Man and a patient heart was used to simulate an atrio-ventricular and a left bundle branch block with 0%, 20% and 40% reduction in interventricular conduction velocity, respectively. The minimum error between physiological excitation and pathology/therapy was automatically computed for 12 different electrode positions. AV and VV delay timing was adjusted accordingly. The results show the importance of individually adjusting the electrode position as well as the timing delays to the patient's anatomy and pathology, which is in accordance with current clinical studies. The presented methods and strategy offer the opportunity to carry out non-invasive, automatic optimization of CRT preoperatively. The model is subject to validation in future clinical studies. © International Federation for Medical and Biological Engineering 2007.
William Hinsberg, Joy Cheng, et al.
SPIE Advanced Lithography 2010
Anupam Gupta, Viswanath Nagarajan, et al.
Operations Research
Xinyi Su, Guangyu He, et al.
Dianli Xitong Zidonghua/Automation of Electric Power Systems
Alessandro Morari, Roberto Gioiosa, et al.
IPDPS 2011