In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers
- David R. Bell
- Jeffrey K. Weber
- et al.
- 2020
- PNAS
Dr. Jeffrey K. Weber is a Senior Research Scientist at the IBM T. J. Watson Research Center, where his focus resides at the interface of statistical physics and computational biology. Dr. Weber received his Ph.D. (Chemical Physics, 2014) from Stanford University, where he combined physics, artificial intelligence, and distributed computing to explore connections between atomistic protein dynamics and functional pathways in cells. As a postdoctoral fellow and later Research Scientist, Staff Research Scientist, and Senior Research Scientist at IBM, Dr. Weber has extended these methods to computational immunology, searching for the molecular processes that underly rare immune control of HIV and the spotty success of cancer immunotherapy. His work continues to focus on applications of molecular dynamics and artificial intelligence to problems in molecular biology and drug discovery, holding a particular focus on Accelerated Discovery for biologic therapeutics design.