F.M. Battiston, J.P. Ramseyer, et al.
Sensors and Actuators, B: Chemical
We report the specific transduction, via surface stress changes, of DNA hybridization and receptor-ligand binding into a direct nanomechanical response of microfabricated cantilevers. Cantilevers in an array were functionalized with a selection of biomolecules. The differential deflection of the cantilevers was found to provide a true molecular recognition signal despite large nonspecific responses of individual cantilevers. Hybridization of complementary oligonucleotides shows that a single base mismatch between two 12-mer oligonucleotides is clearly detectable. Similar experiments on protein A-immunoglobulin interactions demonstrate the wide-ranging applicability of nanomechanical transduction to detect biomolecular recognition.
F.M. Battiston, J.P. Ramseyer, et al.
Sensors and Actuators, B: Chemical
H.P. Lang, M. Hegner, et al.
Nanotechnology
H.P. Lang, R. Berger, et al.
Applied Physics Letters
H.P. Lang, R. Mckendry, et al.
European Cells and Materials