Peter N. Ayittey, John S. Walker, et al.
Pflugers Archiv European Journal of Physiology
Molecular dynamics calculations have been carried out on a model of the LS3 synthetic ion channel in a membrane mimetic environment. In the absence of an external electrostatic field, the LS3 channel, which consists of a bundle of six α-helices with sequence Ac-(LSSLLSL)3-CONH2, exhibits large structural fluctuations. However, in the presence of the field, the bundle adopts a well defined coiled-coil structure with an inner pore of water. The observed structural changes induced by the applied field are consistent with the proposed gating mechanism of the ion channel.
Peter N. Ayittey, John S. Walker, et al.
Pflugers Archiv European Journal of Physiology
Ella Barkan, Ibrahim Siddiqui, et al.
Computational And Structural Biotechnology Journal
Mirvat El-Sibai, Daniel E. Platt, et al.
Annals of Human Genetics
Kristen L. Beck, Niina Haiminen, et al.
mSystems