Design and synthesis of biodegradable grafted cationic polycarbonates as broad spectrum antimicrobial agents

Zhan Yuin Ong; Daniel J. Coady; Jeremy P. K. Tan; Yan Li; Julian Chan; Yi Yan Yang; James L. Hedrick

doi:10.1002/pola.27987

J Polym Sci Part A

Paper

27 Nov 2015

Design and synthesis of biodegradable grafted cationic polycarbonates as broad spectrum antimicrobial agents

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Abstract

Several biodegradable grafted cationic polycarbonates prepared via metal-free organocatalytic ring-opening polymerization are investigated for their antimicrobial activity, mechanism of action, and biocompatibility.

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Broad-spectrum antimicrobial and biofilm-disrupting hydrogels: Stereocomplex-driven supramolecular assemblies

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Mitigated cytotoxicity and tremendously enhanced gene transfection efficiency of PEI through facile one-step carbamate modification

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Highly dynamic biodegradable micelles capable of lysing Gram-positive and Gram-negative bacterial membrane

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Accessing new materials through polymerization and modification of a polycarbonate with a pendant activated ester

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Abstract

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Broad-spectrum antimicrobial and biofilm-disrupting hydrogels: Stereocomplex-driven supramolecular assemblies

Mitigated cytotoxicity and tremendously enhanced gene transfection efficiency of PEI through facile one-step carbamate modification

Highly dynamic biodegradable micelles capable of lysing Gram-positive and Gram-negative bacterial membrane

Accessing new materials through polymerization and modification of a polycarbonate with a pendant activated ester