Analyzing clinical data in XML: Bridging the gaps
Joshua Hui, Sarah Knoop, et al.
IHI 2012
The photochemical 1,3-adduct of benzene to cis-3,4-dichlorocyclobutene has been transformed in four steps to 2,5-endo-10-oxotricyclo[4.3.1.02,5]deca-3,8-diene 1. The key reaction is the acid catalyzed addition of water to the photoadduct 2 which gives the 3,4-dichloroalcohol 3 corresponding to 1. Similarly the photochemical 1,3-adduct of benzene to cyclobutene has also been cleaved with acid. A more convenient synthesis of 1 is provided by the photochemical 1,3-addition of anisole to cis-3,4-dichlorocyclobutene and the treatment of the adduct with acid. The 3,4-dichloro derivative of 1 is thereby obtained directly. Probable mechanisms for these transformations are discussed. © 1975.
Joshua Hui, Sarah Knoop, et al.
IHI 2012
H.L. Ammon, U. Mueller-Westerhoff
Tetrahedron
F. James Rohlf
Mathematical Biosciences
T.L. Fabry, C. Simo, et al.
BBA - Protein Structure