M. Pitman, W.K. Huber, et al.
J. Comput. Aided Mol. Des.
The photochemical 1,3-adduct of benzene to cis-3,4-dichlorocyclobutene has been transformed in four steps to 2,5-endo-10-oxotricyclo[4.3.1.02,5]deca-3,8-diene 1. The key reaction is the acid catalyzed addition of water to the photoadduct 2 which gives the 3,4-dichloroalcohol 3 corresponding to 1. Similarly the photochemical 1,3-adduct of benzene to cyclobutene has also been cleaved with acid. A more convenient synthesis of 1 is provided by the photochemical 1,3-addition of anisole to cis-3,4-dichlorocyclobutene and the treatment of the adduct with acid. The 3,4-dichloro derivative of 1 is thereby obtained directly. Probable mechanisms for these transformations are discussed. © 1975.
M. Pitman, W.K. Huber, et al.
J. Comput. Aided Mol. Des.
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Healthcare financial management : journal of the Healthcare Financial Management Association
David P. Taylor, Govind V. Kaigala
IEEE T-BME
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